Suppose you have a hormone deficiency or overbalance, and you are a man or woman over thirty. As your body ages, it starts producing less of the hormones needed to prevent aging and help you maintain body mass and muscle.
In that case, you may be wondering whether Sermorelin or Ipamorelin would be a better choice for you to help slow down aging and improve your health. What are Ipamorelin and Sermorelin? What are the differences between the two? What kinds of issues do they each address? How do you know which drug therapy would better meet your needs, Sermorelin or Ipamorelin?
Which is Better for Your Needs: Sermorelin vs Ipamorelin?
Before choosing one over the other, you will need to understand what each one does, the results you can expect, and what side effects you might expect while taking it.
What is Ipamorelin?
Ipamorelin is a synthetically created pentapeptide since it contains five amino acid structures. Peptides are created by compounds made from amino acids used to stimulate biological functions in your body when your body no longer has enough of a hormone to do it on its own. Human growth hormone is normally made and sent throughout the body by the pituitary gland by our endocrine system.
We need the human growth hormone in our body to stay healthy and have our organs function normally. Ipamorelin surpasses the growth hormone by inhibiting a hormone called somatostatin which inhibits the amount of human growth hormone produced naturally. This allows more human growth hormones to be produced and used in our bodies.
Ipamorelin stimulates growth hormone to release by mimicking ghrelin. Ghrelin is one of three hormones that act together to get the pituitary gland to release and regulate growth hormones. Ghrelin is also responsible for initiating the fat in your body to break down for energy to help prevent your muscles from breaking down.
Growth hormone is essential to help slow down or prevent aging. Before taking anything that affects your hormones, it is crucial to look at the benefits of taking it versus the potential side effects you may experience. Ipamorelin works to stimulate your body to produce and release growth hormone naturally instead of stopping it like most other synthetic human growth hormones or HGH like many other hormone replacement drugs on the market.
What are the Benefits of Ipamorelin?
Ipamorelin benefits include increases in the production of Insulin-like Growth Factor 1 or IGF-1 to help your body recover quicker from tissue damage and speed up muscle growth. Your body benefits by improving recovery, gaining strength, and creating leaner body mass. The chance of many adverse side effects is reduced when taking Ipamorelin because it is not like other synthetics and has less because it encourages your natural release of growth hormone instead of replacing it.
Even when you use Ipamorelin long-term, there have been very few adverse side effects reported. Ipamorelin has a negligible impact on users’ appetite, prolactin, and cortisol, making it one of the most popular anti-aging peptides.
There are many other Ipamorelin benefits, including:
- improves overall health and wellness.
- users of Ipamorelin have decreased body fat.
- has potent anti-aging benefits.
- may increase performance, energy, and recovery for athletes.
- increases muscle mass.
- enhances your flexibility and improves joint health.
- many users of Ipamorelin experience a night of deeper and more restful sleep.
- helps users experience better recovery from injuries and training sessions.
- faster weight loss is a benefit of using Ipamorelin.
- helps grow and strengthen bones.
- improves skin quality because it can synthesize collagen, which is needed for the formation of all organic structures in the body.
- increases energy and vitality.
- helps promote gut healing and reduces constipation.
- helps the liver to generate IGF-1, which allows the body to regenerate bone and body tissue.
What is the Correct Ipamorelin Dosage?
When used for anti-aging purposes, Ipamorelin should begin with a lower dosage of between 100 and 200 mcg before bed each day should give the patient significant increases in growth hormone production while maintaining a natural release pattern that reduces side effects. Most doctors recommend starting with the lower dosage and gradually increasing it to 200 mcg over a few cycles.
Injections should be taken continuously for a period of eight to twelve weeks for best results. You can then start another cycle of injections if desired with a month off in between cycles. Doses should not be increased during cycles because they may cause adverse side effects. You should avoid eating at least an hour before and after administrating the Ipamorelin dosage. Physicians need to monitor Ipamorelin dosage drug therapy. Physicians can then adjust your Ipamorelin dosage as necessary to provide the required Ipamorelin results.
Once you have your injection of Ipamorelin, a selective pulse is sent to the brain that stimulates the hypothalamus and your anterior pituitary to release growth hormone. Ipamorelin injections help to increase cell synthesis and elevate the secretion levels of insulin from the pancreas.
Although Ipamorelin is available in other forms like oral, nasal, powder, and liquid, the most common and best delivery method is an injection to get the best results. Injections can be intramuscularly or subcutaneously. Injections provide the best absorption and typically give the fastest outcomes.
Athletes and bodybuilders use Ipamorelin in much higher doses and take more than one injection per day. Still, for users wanting anti-aging results and better health, lower doses once a day will provide a more natural and steady release of growth hormone. When appropriately taken, Ipamorelin results are quite good compared to many other peptides used to increase growth hormone.
Potential Side Effects of Ipamorelin
When Ipamorelin is appropriately given and monitored, very few side effects are found and are typically mild. Users do not experience any elevations in the adrenocorticotropic hormone cortisol and prolactin when used as recommended. Ipamorelin side effects users may experience include:
- Temporary nausea after administration of your Ipamorelin dosage.
- Some patients experience a headache with an initial injection. This usually goes away after a few injections.
- Some patients may experience mild flushing.
- Some patients experience feeling tired or lethargic.
- Some interactions between Ipamorelin and other medications you may be taking rarely happen. It is essential to discuss your health conditions and medications with the doctor before starting any drug therapy.
- When patients take excessive dosages of Ipamorelin, some patients retain water and may experience numbness in their hands and feet. Reducing the dosage usually corrects this.
- Temporary redness, itching, or sensitivity at the injection site.
- Dry mouth occurs in some users.
- In rare instances, people develop hypertension when taking too high a dose.
The ipamorelin side effects are minimal compared to many other choices on the market and are rare when administered correctly. The Ipamorelin results leave most users thinking it is well worth the risk compared to the side effects you may encounter.
Ipamorelin and Women
Ipamorelin can be of specific benefit to women after menopause to help reduce the increase in the mineral formation of bones to help prevent fractures. Men and women can have more dense bone mass as they get older, but osteoporosis is a bigger problem for women after menopause. There is some success in Ipamorelin helping to address these issues in recent studies.
What is Sermorelin?
Sermorelin is a synthetically made version of growth hormone-releasing hormone or GHRH. It is categorized as a growth hormone secretagogue that stimulates the pituitary gland to release more growth hormones. Growth Hormone releasing hormone is responsible for stimulating natural growth hormone production.
When you are in your twenties, you typically produce about 500 micrograms of human growth hormone. This decreases as you get older. When you turn thirty, your production of human growth hormone can drop by as much as twenty-four percent and continue to fall each decade from there. By the time you are forty, your growth hormone can be reduced by forty percent.
Some signs your human growth hormones are low include:
- A decreased interest in sex.
- If you begin having fractures easily, it is a sign you have a deficiency in the human growth hormone.
- A loss of stamina or lack of energy is a sign your human growth hormone might be low.
- Belly fat often indicates you have a low percentage of human growth hormone.
If you notice any of these symptoms, you should consider talking to someone by filling out this contact form to schedule a free consultation with one of our doctors.
What are the Benefits of Sermorelin?
The use of Sermorelin helps stimulate natural growth hormone production, which offers many benefits, such as:
- helps increase muscle.
- improved immune system function
- If you desire better organ function Sermorelin helps promote it, including in the kidneys and heart.
- helps increase lean body mass.
- helps decrease body fat which aids in weight loss.
- enhances recovery from injuries and workout sessions.
- unlike some peptides, Sermorelin does not interfere with blood sugar levels.
- helps give users a deep, more restful night’s sleep.
- improved metabolism is experienced by most Sermorelin users.
- improves and promotes health and wellness.
- helps enhance flexibility and joint health.
- when on Sermorelin, patients have better cognitive function.
These are all significant factors to help you stay healthy and moving.
What is the Correct Sermorelin Dosage?
The Sermorelin dosage that is recommended to start is 200mcg. The frequency of the dosage frequency may begin at once per day and gradually increase up to three times per day. Since it may cause you to be sleepy, most doctors recommend you take it right before bed if only taking one shot per day. You may eventually work the Sermorelin dosage up to 1000 mcg. Sometimes you may be told to administer the medication into up to three smaller Sermorelin dosages.
Each Sermorelin dose usually lasts about ten to twenty minutes. The peptide may stimulate the release of growth hormone for about two hours after administering the shot. When taking Sermorelin once per day before bed, the recommended dosage for Sermorelin is ten mcg per 2.2 pounds of body weight.
Potential Side Effects of Sermorelin
Almost all medications have some side effects, but proper administration of the injection is usually the leading cause of side effects from Sermorelin. Some side effects you might experience include:
- Difficulty swallowing when taking Sermorelin is rare but happens
- Changes in taste
- Vomiting is another rare side effect
- Trouble staying still is another rare side effect of Sermorelin
- Some redness and swelling at the injection site
- Drowsiness is a common side effect when you first start taking Sermorelin which is why it is recommended to take your injection before bedtime
- Flushing can happen when taking Sermorelin
If you take medicines or supplements, you will want to share that information with your doctor to ensure you will not have any drug interactions. You should especially talk to your doctor about is any glucocorticoids before starting Sermorelin.
Other things you will want to share with your doctor include any drug allergies you know you have already. You should make sure to mention any allergies you have to food or preservatives. If you are currently pregnant or breastfeeding, you will want to discuss this with a doctor before starting any medication or treatment.
Always follow directions exactly as the package instructions say unless your physician tells you to do it differently.
Sermorelin vs Ipamorelin
There are many benefits that both of these drugs give users. Some of those shared benefits include:
- Increased collagen production.
- Decreased body fat.
- Decreased waistline
- Faster weight loss.
- Increased cell repair and regeneration.
- Increased lean muscles.
- Better sleep at night
- Improvement in the immune system.
- Better athletic performance.
- Increased sexual performance and libido.
While both of these drugs work very well, it should be noted that the best delivery method is by injection for either one.
When deciding between Sermorelin vs Ipamorelin, you will want to look at many factors, including how they work with your body to achieve your goals. Sermorelin works by mimicking growth hormone-releasing hormone to cause the release of more growth hormone. Ipamorelin works in combination with ghrelin by imitating it. Ghrelin helps regulate your metabolism, can increase or decrease your appetite, helps break down stored fat, and helps release growth hormone throughout the body.
Both Ipamorelin and Sermorelin are peptides and send signals to let the body know what to do. Both Ipamorelin and Sermorelin are made from amino acids. Ipamorelin has a combination of five amino acids that make it up, whereas Sermorelin has twenty-nine amino acids.
The FDA has approved the use of Sermorelin but has not yet approved Ipamorelin. Ipamorelin has completed several promising clinical trials. While they both stimulate the pituitary gland to increase the amount of growth hormone released, their chemical structures are quite different, making them act on different receptors.
Ipamorelin has a secondary function which is to reduce somatostatin which inhibits growth hormone. Sermorelin does not have a secondary process. Both of these drugs provide almost the same benefits for the body and usually have very mild to no side effects.
Another difference is in how long after the injection they work. Ipamorelin works about twelve hours after the injection, actively releasing growth hormone. Sermorelin has a limited short life of about twenty minutes after the injection but does increase growth hormone production for about two hours. Both drugs are recommended to take at night so that the growth hormone can peak while you sleep and begin to help your body regenerate itself. You will probably get a little better night to sleep from Sermorelin than Ipamorelin. Sermorelin seems to regulate orexin, which releases neurons in the brain that helps control and regulate sleep.
You should avoid eating simple carbohydrates and sugars before taking your injection of Sermorelin and wait at least one hour before or after eating to get your Ipamorelin injection for best results and not spike your insulin levels.
Sermorelin has a slight lead on Ipamorelin if you look for which of these two peptides works the best for anti-aging properties. Sermorelin is excellent at thickening skin which tends to thin as you get older because of a lack of collagen. It also improves skin collagen structure and improves wound healing.
If you are wondering which of these peptides works best for the pain, it is Ipamorelin. Ipamorelin triggers the release of neuropeptide Y, which is a neurotransmitter that helps control your appetite and food preferences. It is also known to play a role in how we perceive pain.
Lean body mass is another important factor that many people are looking at when deciding the two of them. They both work to improve lean body mass, but Sermorelin works as a growth hormone stimulator and a fat burner. Ipamorelin works more to stimulate growth hormones than to burn fat.
Ipamorelin and Sermorelin both do quite well in healing and help bone grow and work with connective tissue. Ipamorelin does seem to have a little better results than Sermorelin, though.
When choosing between Ipamorelin and Sermorelin, you will need to decide your main goals and then select the one that best promotes the outcome that is important to you. You will want to discuss your desires with your doctor too, so they can help guide you to the best treatment to get the results you want.
Can You Combine a Treatment Using Both Ipamorelin and Sermorelin?
Sometimes experts do recommend a combination of Ipamorelin and Sermorelin. They are both considered to be effective and safe for use. They will give you more energy and an improved lean body mass. They both work well together to provide you with some of the best anti-aging effects making the combination an excellent choice.
Both Ipamorelin and Sermorelin work great to slow down aging and improve your overall health when given by injection. Both Ipamorelin and Sermorelin have very few risks of side effects when taken correctly. The results are outstanding with either of these two drugs for increasing your human growth hormone.
They both deliver outstanding results for weight loss, reducing fat, increasing muscle mass, and improving sleep. They improve your sleep, help repair your cells, and help grow your bones which helps to reduce fractures.
To learn more about Ipamorelin and Sermorelin and how they compare to each other, and the ways they can benefit you, by filling out the contact form on the website to get in touch with our qualified experts and get a free consultation.